This guideline updates and replaces NICE guideline CG64 (2008). The 2015 update was triggered by a study suggesting that the incidence of infective endocarditis may have been affected by the 2008 guidance. As a precaution, NICE reviewed the evidence relating to the effectiveness of prophylaxis against infective endocarditis and found no need to change any of the existing guidance. In addition, NICE concludes that the longstanding increase in the incidence of infective endocarditis in the UK and other countries globally is not well understood and could be due to a number of factors.
This guideline was previously called prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures.
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